Coordination of the nuclear and mitochondrial p53 activities in apoptosis induction.
(A) Shown are the curves for three models: the standard model (solid), the -only model (dashed), and the -only model (dotted). The pro-apoptotic function of mitochondrial p53 is disabled in the -only model, whereas the transcription of genes by nuclear p53 is disrupted in the -only model. (B-D) The contributions of different p53 activities to apoptosis induction. We changed the p53-dependent transcription rate of p21 (B), the p53-dependent transcription rate of PUMA (C), and the translocation rate of (D), respectively. Displayed are the curves for different cases.