Line-Tension Controlled Mechanism for Influenza Fusion (original) (raw)
Figure 3
Evolution of a stalk in the absence and presence of a pore.
For sake of clarity the size of the lipid headgroups is exaggerated (solvent is not shown). (A) Two apposed DOPC bilayers. A preformed stalk is not stable (see Fig. 4). (B) A stable ‘hour-glass shaped’ stalk structure formed between a DOPE and DOPC bilayer (4 µs). (C) Elongation of a stalk formed between two DOPE bilayers (4 µs). (I-III) Evolution of a stalk formed between two DOPC bilayers in the vicinity of a pore (stalk-pore complex). Elongation of the stalk, which circumvents the pore, results in the formation of a -shaped hemifusion diaphragm (
-HD).