Impaired LDL Receptor-Related Protein 1 Translocation Correlates with Improved Dyslipidemia and Atherosclerosis in apoE-Deficient Mice (original) (raw)
Figure 2
VLDL production, postprandial triglyceride response, intestinal lipid absorption and TRL clearance in apoE−/− (Δ or □) and ApoE−/−LRP1n2/n2 (▪) mice.
A–C, VLDL production after a Tyloxapol injection to inhibit lipolysis (A), postprandial triglyceride response after gastric olive oil load (B) and lipid absorption and chylomicron production after a combined gastric olive oil load and Tyloxapol injection (C) (n = 6–10 per genotype). D, Postprandial accumulation of 3H-Triolein in liver, white adipose tissue (WAT) and proximal (Prox.), medial (Med.) and distal (Dist.) intestine 2 h after a gastric load with olive oil mixed with 3H-Triolein (E) (n = 5 per genotype). Data are mean±SEM. *P<0.05, **P<0.001.