Mesenchymal Cell Interaction with Ovarian Cancer Cells Triggers Pro-Metastatic Properties (original) (raw)
Figure 4
MC protects OCC from chemotherapy induced cell death.
A. Explanative scheme of FACS analysis. B. OCC or OCC co-cultivated with MSC were treated for 48 hours with 90 µM of Cisplatin and 6 nm of Paclitaxel. Cell types were discriminated by FACS using GFP as a cancer cell marker, and CD73 as an MC marker. Cell death analysis was carried out using the dual Calcein/Live Dead staining. C. Quantitation of cell death analysis experiments. OCC display a resistance to conventional chemotherapy treatment when co-cultivated with MC compared to the control. SEM are represented, n = 3, | p<0.05 t-Student Test.