Molecular Resistance Fingerprint of Pemetrexed and Platinum in a Long-Term Survivor of Mesothelioma (original) (raw)
Figure 2
Pyrimidine metabolism in tumour versus normal and at acquired resistance.
Genes involved in pathways of DNA metabolism and production in tumour versus normal (red corresponds to overexpressed and dark green correspond to down-regulated) and in acquired resistant tumour (in ovals, all were overexpressed). Abbreviations: 2.1.3.2 = aspartate transcarbamylase 3.5.2.3 = dihydroorotase 6.3.5.5 = CAD; carbamoyl-phosphate synthetase 2 3.1.3.5 = NT5C; 5′-nucleotidase 2.7.7.7 = POLA2; DNA polymerase alpha subunit B 2.7.7.7 = POLD1; DNA polymerase delta subunit 1 1.17.4.1 = RRM2B; ribonucleoside-diphosphate reductase subunit M2 2.4.2.4 = TYMP; thymidine phosphorylase.