Inflammation Drives Dysbiosis and Bacterial Invasion in Murine Models of Ileal Crohn’s Disease (original) (raw)
Figure 4
Inflammation drives dysbiosis, Gram negative proliferation and E. coli invasion.
Independent of genotype, ileitis induces a progressive decrease in microbial diversity, a shift from Firmicutes (Gram**+**) to Proteobacteria (Gram−), and proliferation of AIEC. Superimposition of genetic susceptibility can lower (NOD2−/−) or increase (CCR2−/−) the threshold for dysbiosis in response to an external trigger. We speculate that genetic susceptibility may also influence the ability of an individual to resolve the self-perpetuating cycle of dysbiosis and inflammation generated by an acute insult.