Epstein-Barr Virus Immortalization of Human B-Cells Leads to Stabilization of Hypoxia-Induced Factor 1 Alpha, Congruent with the Warburg Effect (original) (raw)
Figure 5
Expression of HIF1A-responsive genes in EBV-infected and mitogen-activated B-cells and LCLs.
Expression of HIF1A-responsive genes, assessed by Q-PCR. CD40+IL4-activated (ABC) and freshly EBV-infected (EBC) B-cells were compared with LCLs. Untreated and cells treated with NiCl2 were compared. Notice that many genes are upregulated in LCL and freshly EBV-infected cells, compared with CD40+IL4-activated B-cells.