Age-Associated Changes In Oxidative Stress and NAD+ Metabolism In Human Tissue (original) (raw)
Figure 1
Effect of age on tissue lipid peroxidation in (A) males (B) females.
(A) Lipid peroxidation increases with age in male subjects. MDA levels in human tissue increased significantly with age in males aged between 0–77 years (Line a; p = 0.0003; n = 27). Line b shows post-pubescent (males only) data (p = 0.0044; n = 19). Spearman's correlation coefficient for the non-normally distributed population was r = 0.643 and r = 0.623 for line a, and line b respectively. An exponential (first-order) least squares fit was used to generate the nonlinear trend lines (line a and b). (B) Changes in lipid peroxidation with age in female subjects. The apparent increase in MDA levels in post-pubescent females (36–76 years) is not statistically significant (p = 0.3734; n = 22). Spearman's Correlation coefficient for a non-normally distributed population was 0.200. An exponential (first-order) least squares fit was used to generate the nonlinear trend line.