Age-Associated Changes In Oxidative Stress and NAD+ Metabolism In Human Tissue (original) (raw)
Figure 5
Correlation between SIRT1 Activity and Age in (A) Males (B) Females.
(A) SIRT1 activity declines with age in post-pubescent males. The apparent negative correlation in SIRT1 activity with age in males aged between 0–77 years was not statistically significant (line a; p = 0.0385; n = 27). Spearman's correlation coefficient for a non-normally distributed population, r = −0.400. Line b represents the post-pubescent data shows a significant negative correlation with age (r = −0.612; p = 0.007; n = 19). An exponential (first-order) least squares fit was used to generate the nonlinear trend lines (line a and b). (B) Changes in SIRT1 with age in females. The apparent increase in PARP activity with age (36–76 years) is not statistically significant (p = 0.3743; n = 22). Spearman's correlation coefficient for a non-normally distributed population,r = 0.194. An exponential (first-order) least squares fit was used to generate the nonlinear trend line.