Age-Associated Changes In Oxidative Stress and NAD+ Metabolism In Human Tissue (original) (raw)

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Figure 6

(A) Lipid peroxidation increases significantly in parallel to increased DNA damage in post pubescent males (p<0.0001).

The subjects were aged between 15–77 years (n = 19). Spearman's correlation coefficient, r = 0.7209. An exponential (first-order) least squares fit was used to generate the nonlinear trend line. (B) PARP activity decreases in line with a decline in NAD+ levels in post pubescent male subjects (p = 0.0149). . The subjects were aged between 15–77 years (n = 19). Pearson's correlation coefficient,r = −0.5491 An exponential (first-order) least squares fit was used to generate the nonlinear trend line. (C) Correlation between NAD+ levels and SIRT1 activity in post pubescent male subjects. The subjects were aged between 15–77 years (n = 19). The correlation is not of statistical significance (p = 0.9829). Pearson's correlation coefficient,r = −0.005263.

Figure 6

doi: https://doi.org/10.1371/journal.pone.0042357.g006