Low Bone Turnover and Low BMD in Down Syndrome: Effect of Intermittent PTH Treatment (original) (raw)
Figure 1
Trisomy effects on the proximal tibia and femur or 3-month and 24-month Ts65Dn mice.
(A) Micro CT reconstructions of metaphyseal tibial cancellous bone in 3-month (left column) and 24-month (right column) old WT (top) and Ts65Dn (bottom) mice. The low bone volume is evident at 3-months in the Ts65Dn mice vs. WT. (B). Micro CT analysis of % bone volume/tissue volume (BV/TV), trabecular number (Tb.N.), trabecular thickness (Tb.Th.), trabecular separation (Tb.Sp) in Ts65Dn 3-month and 24-month old WT and Ts65Dn proximal tibia. (C). Decreased cortical thickness at the femoral midshaft by micro CT in 24 month old WT and Ts65Dn mice. Representative MicroCT reconstructions of the midshaft and measurement of cortical thickness in both WT and Ts65Dn are shown. *, p<0.05 vs. WT.