Origins of Albino and Hooded Rats: Implications from Molecular Genetic Analysis across Modern Laboratory Rat Strains (original) (raw)
Figure 1
Linkage and haplotype mapping of the hooded (H) locus.
Left: Haplotypes of backcross progeny carrying the recombinant chromosome between D14Rat84 and D14Got40. The grey boxes represent rats homozygous for genetic markers, while the white boxes represent rats heterozygous for genetic markers. The coat pattern phenotypes of the progeny and the number of the progeny for each haplotype are described above and below the haplotypes, respectively. The H locus was narrowed down from D14Rat13 to D14Got40 (boxed with a solid line). Right: SNP haplotypes around the H locus in representative inbred rat strains. Two hooded rat strains and one Irish rat strain shared the identical haplotype of the genomic region between ENSRNOSNP2799338 and ENSRNOSNP2799342. The genomic region that was shared among the four self strains was narrowed down from ENSRNOSNP2799339 to ENSRNOSNP2799341 (boxed with a solid line). The linkage and haplotype analyses demonstrated that the hooded locus was mapped to the region defined by D14Rat13 and ENSRNOSNP2799341 (boxed with a dashed line).