Effect of Maternal Probiotic Intervention on HPA Axis, Immunity and Gut Microbiota in a Rat Model of Irritable Bowel Syndrome (original) (raw)
Figure 3
Effect of maternal probiotics, stress and gender on adult corticosterone levels.
A) Effect of maternal probiotic intervention and sex on natural log (Ln) transformed plasma corticosterone levels (LnCort, least squares means+SE). Initial corticosterone data were expressed as ng/mL plasma. The figure presents aggregated data across test days (PND 24 and 86). Hollow bars represent males: male vehicle (n = 71), male probiotic (n = 53). Filled bars represent females: female vehicle (n = 62), female probiotic (n = 58). B) Effect of maternal probiotic intervention and adult restraint stress on Ln-transformed plasma corticosterone concentrations (LnCort, least squares means+SE) in adulthood (week 12).Hollow bars represent animals exposed to no-stress in adulthood (NA): NA vehicle (n = 39), NA probiotic (n = 35). Filled bars represent animals exposed to stress in adulthood (AS): AS vehicle (n = 39), AS probiotic (n = 36). C) Effect of adult restraint stress and sex on Ln-transformed plasma corticosterone concentrations (LnCort, least squares means+SE) in adulthood (week 12). Hollow bars represent males: NA male (n = 35), AS males (n = 36). Filled bars represent females: NA females (n = 39), AS females (n = 39). An asterisk (*) indicates statistical significant difference (_p_≤0.05).