Effect of Maternal Probiotic Intervention on HPA Axis, Immunity and Gut Microbiota in a Rat Model of Irritable Bowel Syndrome (original) (raw)
Figure 10
Effect of maternal probiotic intake, stress and gender on faecal counts of E. coli.
A) Effect of sex on faecal counts of E. coli (Log CFU/gr, least squares means+SE) in rats. The figure presents aggregated data across test days (PND 24 and 86).The hollow bar represents males (M, n = 109) and the filled bar represents females (F, n = 112). An asterisk (*) indicates statistical significant difference (_p_≤0.05). B) Effect of maternal probiotic intake and neonatal maternal separation (MS) on faecal counts of E. coli (Log CFU/gr, least squares means+SE). The figure presents aggregated data across test days (PND 24 and 86).The hollow bars represent animals exposed to no-MS (NS): NS vehicle (n = 52), NS probiotic (n = 51). The filled bars represent animals exposed to MS: MS vehicle (n = 60), MS probiotic (n = 56). An asterisk (*) indicates statistical significant difference relative to vehicle NNS animals (p≤0.05). C) Effect of MS and AS on faecal counts of E. coli (Log CFU/gr, least squares means+SE) in adult Wistar rats (week 12). The hollow bars represent no-stress control animals or those exposed to AS: control (n = 33), AS (n = 37). The filled bars represent animals exposed to MS or MS+AS: MS (n = 38), MS+AS (n = 39). An asterisk (*) indicates statistical significant difference compared to the control (_p_≤0.05). D) Effect of maternal probiotic intake and AS on faecal counts of E. coli (Log CFU/gr, least squares means+SE) in adult Wistar rats (week 12). The hollow bars represent animals exposed to no-AS (NA): NA vehicle (n = 38), NA probiotic (n = 33). The filled bars represent animals exposed to AS: AS vehicle (n = 40), AS probiotic (n = 36). An asterisk (*) indicates statistical significant difference relative to vehicle NAS animals (_p_≤0.05).