Small Mutations in Bordetella pertussis Are Associated with Selective Sweeps (original) (raw)
Figure 3
Frequency of allele types and genetic diversity of the Dutch B. pertussis population in the period 1949–2010.
The diversity index (DI) and 95% confidence interval (CI) for each period, based on the sequence types (STs), were calculated using the Hunter and Gaston's modification (Hunter and Gaston 1988) of the Simpson's diversity index and are indicated. Frequencies of allele types are calculated for each period and coloured as in Fig. 1. Significant differences in DI between periods are indicated with asterisks. Abbreviations: AT, allele type; N, number of strains; DI, diversity index; CI, 95% confidence interval.