In Vivo Anti-HIV Activity of the Heparin-Activated Serine Protease Inhibitor Antithrombin III Encapsulated in Lymph-Targeting Immunoliposomes (original) (raw)
Figure 5
In vivo anti-viral activity of ET-ATIII in rhesus macaques.
Chronically SIVmac239 infected rhesus macaques (n = 2) were treated with 1.5 ml ET-ATIII (0.3 nmol/kg encapsulated hep-ATIII) at indicated time points depicted by arrows. (A) Viral load of ET-ATIII treated animals as RNA copies/ml. (B) Log10 reduction of viral load. Vehicle liposomes were used as a control. Viral load was measured and compared to animals before treatment (day 0). Data are shown as mean ± S.E.