From Understanding the Development Landscape of the Canonical Fate-Switch Pair to Constructing a Dynamic Landscape for Two-Step Neural Differentiation (original) (raw)
Figure 3
The developmental landscape and dominant paths under different noises.
As the noise increases, the developmental landscape becomes flatter while the dominant paths on the landscape become increasingly straight. Thus the cell types become less stable and the development (and also the retrodifferentiation and transdifferentiation) process(es) becomes more flexible. The same conclusions apply to _k_-change landscape (Here it is the _a_-change landscape). This graph demonstrates the importance of stochasticity in cellular development. (A–D) Landscape and dominant paths when ,
,
and
, respectively. Red color lines: development paths; yellow color lines: retrodifferentiation paths; magenta color lines: transdifferentiation paths.