Acidic Nanoparticles Are Trafficked to Lysosomes and Restore an Acidic Lysosomal pH and Degradative Function to Compromised ARPE-19 Cells (original) (raw)
Figure 6
Model of enhanced photoreceptor degradation.
A. RPE cells with compromised lysosomes cannot sufficiently degrade photoreceptor outer segments. The undigested material accumulates inside the cell as autofluorescent lipofuscin. B. After treatment with acidic nanoparticles, RPE lysosomes are more capable of breaking down the POS. The end result is a substantial decrease in undigested debris and lipofuscin.