Molecular Characterization of the Predominant Influenza A(H1N1)pdm09 Virus in Mexico, December 2011–February 2012 (original) (raw)
Figure 2
Amino acid substitutions in the HA antigenic sites of the 2012 influenza A H1N1 Mexican isolates.
Amino acid sequences are shown for the HA antigenic region of the four fully sequenced 2012 Mexican isolates (MX2012a-d, GenBank accession numbers JQ714072–JQ714075 respectively), the reference California 2009 isolate (CA2009, accession number CY054707) and a reference 2009 Mexican isolate (MX2009, accession number GQ402189). Amino acid positions are numbered without considering the HA signal peptide. Amino acid substitutions in the 2012 Mexican isolates are marked in red. Antigenic sites are shaded: Sa – purple, Sb – yellow, Ca – green, Cb – blue. Substitutions S69T, S143G, K163R, S185T, S203T and A197T are shown to be within or adjacent to antigenic sites.