Characterization of Neurophysiological and Behavioral Changes, MRI Brain Volumetry and 1H MRS in zQ175 Knock-In Mouse Model of Huntington's Disease (original) (raw)
Figure 6
In vivo MRS in the striatum of Q175 and WT mice.
(A) Representative T2-weighted MRI and localized volume from which the (B) MR spectra were recorded. (C) The concentrations of striatal metabolites at 12 months of age as measured by MR spectroscopy. Data are presented as mean SEM. Abbreviations: GABA, gamma-aminobutyric acid; GLN, glutamine; GLU, glutamate; INS, myo-inositol; NAA, N-acetylaspartate; TAU, taurine; CHO, choline; NAA+NAAG, N-acetylaspartate+N-acetylaspartylglutamate; CR+PCR, creatine+phosphocreatine; GLU+GLN, glutamate+glutamine. Data are presented as mean ± SEM. * p<0.05 zQ175 HOMO mice vs. zQ175 WT mice; # p<0.05 zQ175 HET mice vs. zQ175 WT mice (zQ175 WT, n = 10; zQ175 HET, n = 10; zQ175 HOMO, n = 9).