Systems Biology Approach Reveals Genome to Phenome Correlation in Type 2 Diabetes (original) (raw)
Figure 3
Overlap between antidiabetic drug interacting genes and T2D interactome.
Compared to total interactome of 14,306 genes, the T2D interactome of 561 genes represent significantly greater number of antidiabetic drug interacting genes. A statistically significant overrepresentation was observed for all the drugs except pioglitazone in hypergeometric test with Bonferroni adjustment of p values for multiple hypotheses testing. Overrepresentation with a borderline significance was nonetheless observed even for pioglitazone. The adjusted enrichment p values are indicated.