In Vivo MR Imaging of Intraarterially Delivered Magnetically Labeled Mesenchymal Stem Cells in a Canine Stroke Model (original) (raw)
Figure 4
Three types of ischemic infarction and the amount of grafted MSCs in the target brain.
Moderate size of cerebral infarction involving the left temporal lobe (A), large infarction in left MCA territory (B) and small infarction located in subcortical white matter (C) were got after combining left proximal MCA embolization with two-hour left ICA blood flow occluding. All these three dogs (dog 5, 12 and 13) had complete left MCA recanalization before transplantation (not shown). After intra-carotid MSCs transplantation, dog with large infarction had more obvious MSCs in the brain than that with moderate size of infarction (D-E), while dog with very small infarction was shown fewer scattered cells (F).