Stimulation of the Sigma-1 Receptor by DHEA Enhances Synaptic Efficacy and Neurogenesis in the Hippocampal Dentate Gyrus of Olfactory Bulbectomized Mice (original) (raw)
Figure 1
DHEA ameliorates perturbed LTP in the DG of OBX mice.
A: Representative fEPSPs were recorded from the DG in sham-operated mice, OBX mice, DHEA (60 mg/kg p.o.)-treated OBX mice, and DHEA plus NE-100 (1 mg/kg p.o.)-treated OBX mice. B: Changes in fEPSP slope following HFS recorded in the DG were attenuated in OBX compared with sham-operated mice. DHEA treatment significantly improved LTP in OBX mice. NE-100 significantly inhibited enhancement of LTP mediated by DHEA in OBX mice. C: Changes in fEPSP slope following HFS are shown in sham-operated, OBX, DHEA-treated OBX, and DHEA plus NE-100-treated OBX mice at 1 or 60 min. Vertical lines show SEM. **, p<0.01 versus sham-operated mice. ++, p<0.01 versus OBX mice. ##, p<0.01 versus DHEA-treated OBX mice.