Sex Bias in Experimental Immune-Mediated, Drug-Induced Liver Injury in BALB/c Mice: Suggested Roles for Tregs, Estrogen, and IL-6 (original) (raw)
Figure 11
Ovariectomy reduces anesthetic DILI in female BALB/c mice.
Intact BALB/c females and males as well as females who had undergone ovariectomy were immunized with TFA-S100 as described in the Methods. By 3 weeks, the intact females had developed significantly more severe hepatitis (A, *p<0.05) and exhibited significantly higher levels of TFA IgG1 antibody levels (B) compared to ovariectomized (OVX, *p<0.05) or male mice (**p<0.01, n = 4 mice/group). (C) Splenic IL-6 levels were significantly higher in intact female mice than in OVX or male mice at 2 weeks after immunizations. (Mann-Whitney U, * = p<0.05, ** = p<0.01).