A Protein Prioritization Approach Tailored for the FA/BRCA Pathway (original) (raw)
Figure 3
GO enrichment top 150 of Ranked, Nermal, and FuncNet.
Number of genes observed with the GO terms “response to DNA damage stimulus” (GO:0006974) and “DNA repair” (GO:0006281) in the top 150 of our combined ranking approach “Ranked”, the literature mining tool “Nermal”, and the protein function prediction tool “FuncNet”. Number of genes observed, number of genes expected (P-value) for GO term “response to DNA damage stimulus” (GO:0006974): Ranked 71, 5 (5.50E−64); Nermal 65, 5 (7.10E−56); FuncNet 53, 5 (4.27E−42). GO term “DNA repair” (GO:0006281): Ranked 61, 4 (1.28E−60); Nermal 62, 3 (1.24E−62); FuncNet 47, 3 (1.54E−42).