Tau Passive Immunotherapy in Mutant P301L Mice: Antibody Affinity versus Specificity (original) (raw)
Figure 4
Representative CP13 and RZ3 immunohistochemistry of immunized P301L mice, 7 to 10 months of age.
The CA1 hippocampal region of the MC1 treated mice was stained with two different phospho-tau antibodies. a–b) CP13 (pSer202) staining is significantly reduced after injecting MC1, both when comparing 7 and 10 months old controls mice with MC1 treated animals from 7 to 10 months of age (p = 0.016 and p = 0.036 respectively). c–d) RZ3 (pThr231) immunoreactivity displays a significant decrease in mice treated with MC1 from 7 to 10 months of age (p = 0.013). Results are expressed as percent of area stained.