HnRNP A1/A2 and SF2/ASF Regulate Alternative Splicing of Interferon Regulatory Factor-3 and Affect Immunomodulatory Functions in Human Non-Small Cell Lung Cancer Cells (original) (raw)

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Figure 7

HnRNP A1/A2, SF2/ASF, and IRF-3 are over-expressed in human NSCLC tumor tissues.

Representative images showing staining for hnRNP A1/A2, SF2/ASF, or IRF-3 with specific antibody of fixed lung sections of either NSCLC tumor tissue, non-tumor tissue, or bronchiectasis tissue. Positive hnRNP A1/A2 or SF2/ASF expression was shown as brown staining predominantly in the cell nucleus, while positive IRF-3 expression in both the cytoplasm and the nucleus. Section without antibody treatment was used as negative control. Original magnification, ×400.

Figure 7

doi: https://doi.org/10.1371/journal.pone.0062729.g007