miR-219-5p Inhibits Receptor Tyrosine Kinase Pathway by Targeting EGFR in Glioblastoma (original) (raw)
Figure 1
miR-219-5p is downregulated in glioblastoma.
Expression of miR-219-5p in malignant astrocytoma [anaplastic astrocytoma (AA) and glioblastoma (GBM)] as compared to the control normal brain tissue (Normal) is plotted as scatter plot. A. From the miRNA microarray data, miR-219-5p expression was found to be significantly downregulated in anaplastic astrocytoma (AA; n = 13) and glioblastoma (GBM; n = 26) with a p value of 0.0024 (from Kruskal-Wallis test in One-Way ANOVA). B. In the real-time qPCR validation set, miR-219-5p expression was found to be significantly downregulated in glioblastoma (GBM; n = 24) with a p value of 0.0098 (from Mann-Whitney test). C. In the TCGA dataset, miR-219-5p expression was found to be significantly downregulated glioblastoma (GBM; n = 492) with a p value of <0.0001 (from Mann-Whitney test).