In Vitro and In Vivo Models of Cerebral Ischemia Show Discrepancy in Therapeutic Effects of M2 Macrophages (original) (raw)
Figure 5
M2 macrophages do not reduce lesion size after ischemic stroke.
A- Typical T2-weighted images obtained at D3, D7 and D14 post-ischemia showing the lesion as a hyperintense signal. B- The ratio of hemisphere volumes [ipsilateral:contralateral] showed moderate brain swelling at D3, normalization at D7 and moderate atrophy at D14. No statistically significant difference was seen between treatment groups (analysis of variance for repeated measures, N = 8 in each group, p = 0.941). C- Before treatment (D3), lesion volume (corrected for brain swelling/atrophy) was not significantly different between groups. Likewise, after treatment (D7 and D14), there was no significant difference between groups (analysis of variance for repeated measures, N = 8 in each group, p = 0.346).