Primary Cilia Are Lost in Preinvasive and Invasive Prostate Cancer (original) (raw)
Figure 3
Frequency of cilia does not change on stromal cells surrounding cancer.
Images of (A) normal prostate and (B) prostate cancer show nuclei (Hoechst; blue), cytokeratin 5 (CK5; white), primary cilia (Ac-Tub; red) and centrosomes (γ-Tub; green). Inset shows magnification of primary cilia on stromal cells associated with (A) normal tissue and (B) cancerous tissue (C, top). Boxplot describe the percent ciliated stromal cells per patient for each tissue type: normal, prostatic intraepithelial neoplasia (PIN), cancer (Ca), and perineural invasion (Peri). Q4, Q1 are as in Figure 1 (C, bottom). The percent of patients with an abnormally high percent cilia (Q4; orange) or an abnormally low percent cilia (Q1; blue).