Differential Sensitivity of Bat Cells to Infection by Enveloped RNA Viruses: Coronaviruses, Paramyxoviruses, Filoviruses, and Influenza Viruses (original) (raw)
Figure 3
Susceptibility of bat cell lines to infection mediated by the S proteins of two bat-derived SARSr-CoVs, Rp3 and Bg08.
VSV pseudotyped with either SARS-CoV SΔ18 (SARS SΔ18), SARSr-CoV Rp3 SΔ18 (Rp3 SΔ18), or SARSr-CoV Bg08 SΔ18 (Bg08 SΔ18) were applied to confluent bat cells and infection efficiency was determined by measuring the luciferase activity 18 h p.i.. VSV pseudotypes generated with VSV G (VSV G) or with an empty pCG1 vector alone (empty vector) served as positive and negative controls, respectively. All tests were performed in quadruplicates and the data shown are the result of three independent experiments.