Notch-1 Signaling Regulates Microglia Activation via NF-κB Pathway after Hypoxic Exposure In Vivo and In Vitro (original) (raw)
Figure 10
NICD expression was increased in the corpus callosum of neonatal rats following hypoxic exposure.
Confocal images showing the expression of NICD (red) in the corpus callosum of neonatal rats 3 and 7 days after hypoxia and the corresponding control. Microglial cells were labeled with lectin (green). Very week NICD immunofluorescence intensity was observed in lectin-positive microglia in the control rats of both 3 (b–c) and 7 (g–i) days. NICD immunofluorescence intensity in microglia is enhanced after hypoxic exposure at 3 (d–f) and 7 (j–l) days after hypoxia, especially at 3 days (d–f) in comparison with the control (j–l)). Nuclei are stained with DAPI (blue). Scale bars = 20 µm.