The Gene Expression Profile of Peripheral Blood Mononuclear Cells from EV71-Infected Rhesus Infants and the Significance in Viral Pathogenesis (original) (raw)
Figure 1
EV71 infection induced changes in the gene expression in PBMCs from infected rhesus infants.
(a) A global view of the gene modulation in the PBMCs of infected infants at days 4, 7 and 10 p.i., is shown as a Venn Diagram. The colors indicate the number of significantly modulated genes at day 4 (red), 7 (purple) and 10 p.i. (yellow). Different sets show the number of modulated genes at different time point. Set 1: the modulated genes at day 4 p.i.; Set 2: at day 7 p.i.; Set 3: at day 10 p.i.; Set 4: at days 4 and 7 p.i.; Set 5: at days 4 and 10 p.i.; Set 6: at days 7 and 10 p.i.; Set 7: at days 4, 7 and 10 p.i.. (N = 6 in experimental group; N = 3 in control group). (b) Distribution of GO term identified in comparisons of monkeys infected with and without EV71. Gene ontology analysis of the differential genes in the PBMCs from infected and un-infected infants during 4, 7 and 10 days p.i.. The values are shown on a log2 P-value scale.