A Monoclonal Antibody TrkB Receptor Agonist as a Potential Therapeutic for Huntington’s Disease (original) (raw)
Figure 1
TrkB signaling and assay cascades.
(A) TrkB signalling cascade showing proximal and distal assay measurement points. Red arrows represent BDNF-induced trans-phosphorylation events within the intracellular tyrosine kinase domains. Changes in TrkB phosphorylation/activation detected by (1) Invitrogen CellSensor®; (2) DiscoveRx PathHunter®; and (3) MSD® pAKT assays. (B) Screening cascade used to characterize TrkB modulators.