ZiBuPiYin Recipe Protects db/db Mice from Diabetes-Associated Cognitive Decline through Improving Multiple Pathological Changes (original) (raw)
Figure 3
Effects of ZBPYR on Aβ1-42 deposition and the expression of neurostructural proteins in different regions of brain.
(A) Aβ1-42 deposition in the PFC, hippocampal CA1 and DG were visualized using immunohistochemistry. (B) The expression of MAP2 in the PFC and hippocampal CA1 was visualized using immunohistochemistry. (C) The expression of PSD95 in the hippocampal CA1 was visualized using immunohistochemistry. (D–F) The average IOD of the immunoreactive area for Aβ1-42, MAP2 and PSD95, are presented as bar graphs. ZBPYR significantly reduced Aβ1-42 deposition in the PFC and hippocampal CA1 and DG (D). ZBPYR significantly increased the expression of MAP2 in the PFC and hippocampal CA1 (E). ZBPYR significantly increased the expression of PSD95 in the hippocampal CA1 (F). Scale bar = 100 µm. Values are means ± S.D. from 3 mice in each group. *p<0.05 compared to control; #p<0.05 compared to DM.