Forced Resurgence and Targeting of Intracellular Uropathogenic Escherichia coli Reservoirs (original) (raw)
Figure 4
Chitosan treatment enhances the efficacy of antibiotics in reducing bacterial titers within the bladder.
Mice were infected with UTI89 via transurethral catheterization 3% chitosan. After a 20-min incubation and subsequent washes with PBS, mice were treated for 3 or 7 d with gentamicin (GENT), sparfloxacin (SPX), or ciprofloxacin (CIP), as indicated. Mice were sacrificed 3 d after cessation of antibiotics or mock treatments. An outline of the experimental setup is shown on top. Bars in the graph indicate median values for each sample group; n = 11 mice total from two independent assays. *P<0.02, **P<0.005, ***_P_≤0.0002; as determined by Mann-Whitney U-tests.