A Bayesian Method to Incorporate Hundreds of Functional Characteristics with Association Evidence to Improve Variant Prioritization (original) (raw)
Figure 2
Heat map of correlations among the separated functional characteristics.
A full list of the numbered characteristics is provided in Table S1. The white box in the bottom left corner corresponds to high correlation among the histone modifications. The less defined white area spanning from 72 to 219 on the x axis corresponds to correlation among the transcription factor binding sites, which also show some correlation with the histone modifications. The white box from 220 to 319 on the x axis corresponds to a high correlation among the different cell types for the DNase I hypersensitivity characteristic from Duke University. The less refined white box from around 320 and onwards on the x axis corresponds to the DNase I characteristics from the University of Washington. The plot also shows some correlation among the DNase I characteristics from both groups.