Long-Term Treatment with the Sodium Glucose Cotransporter 2 Inhibitor, Dapagliflozin, Ameliorates Glucose Homeostasis and Diabetic Nephropathy in db/db Mice (original) (raw)
Figure 4
Dapagliflozin suppresses inflammatory gene expression in the renal cortex.
Quantitative RT-PCR analysis of the expression of TGF-β (A), MCP-1 (B), osteopontin (C) and ICAM-1 (D) showed that dapagliflozin inhibited diabetes-induced inflammation in the kidney. mRNA levels were normalized against Atp5f1 expression. Data are mean ± SEM. *P<0.05.