Metabolomics Analysis Identifies Intestinal Microbiota-Derived Biomarkers of Colonization Resistance in Clindamycin-Treated Mice (original) (raw)
Figure 3
Changes in levels of fecal metabolites of clindamycin-treated mice compared to saline controls for selected compounds that exhibited a sustained increase or decrease after clindamycin treatment.
Compounds from pathways related to metabolism of (A) creatinine, (B) bile salts, (C) phytoestrogens, (D) N-acetylated amino acids and (E) short-chain fatty acids. Results from experimental mice are shown on the left and from control animals on the right. Metabolites measured in the experimental group are the significantly different (_p_≤0.05) from the pre-treatment levels at least through day 8 after the final clindamycin dose for all compounds except N-acetyl-aspartate (_p_≤0.10 at days 5, 8; _p_≤0.5 all other times). Error bars represent standard error.