Metabolomics Analysis Identifies Intestinal Microbiota-Derived Biomarkers of Colonization Resistance in Clindamycin-Treated Mice (original) (raw)
Figure 5
Changes in levels of fecal metabolites of clindamycin-treated mice compared to saline controls for selected compounds that increased or decreased in concentration during clindamycin treatment followed by normalization or substantial return toward baseline within 8 days.
Compounds from pathways related to metabolism of (A) dipeptides, (B) inositol isomers and metabolites and (C) gamma-glutamyl amino acids. Results from experimental mice are shown on the left and from control animals on the right. Methyl-chiro-inositol uses the right axis. Metabolites measured in the experimental group are the significantly different (_p_≤0.05) from the pre-treatment levels through day 1 (pyroglutamylglutamine, gamma-glutamylleucine, gamma-glutamylvaline, gamma-glutamylphenylalanine, gamma-glutamyltyrosine), day 5 (proline-hydroxy-proline, myo-inositol, gamma-glutamylglutamate), and day 8 (chiro-inositol, methyl-chiro-inositol, gamma-glutamylmethionine) except gamma-glutamylisoleucine (_p_≤0.10 through day 8). Error bars represent standard error.