Metabolomics Analysis Identifies Intestinal Microbiota-Derived Biomarkers of Colonization Resistance in Clindamycin-Treated Mice (original) (raw)
Figure 6
Changes in fecal levels of compounds related to tryptophan metabolism in clindamycin-treated mice compared to control animals.
(A) A schematic representation of mammalian metabolism of dietary tryptophan. Biochemical pathways specific to the host are indicated in dashed lines and to the microbiota in solid lines. Fecal levels of compounds with metabolic pathways dependent, at least in part, on the gut microbiota (B) or solely on the host (C). Results from experimental mice are shown on the left and from control animals on the right. Metabolites measured in the experimental group are the significantly different (_p_≤0.05) from the pre-treatment levels through day 1 (indolepropionate, kyurenate), at day 5 (indolelactate) or days 5 – 21 (N-acetyletryptophan). Error bars represent standard error.