Metabolomics Analysis Identifies Intestinal Microbiota-Derived Biomarkers of Colonization Resistance in Clindamycin-Treated Mice (original) (raw)
Figure 9
Changes in levels of fecal metabolites of piperacillin/tazobactam-treated mice compared to saline controls for selected compounds that exhibited a sustained increase or decrease after clindamycin treatment.
Compounds from pathways related to metabolism of (A) creatinine, (B) bile salts; (C) phytoestrogens (D) N-acetylated amino acids and (E) short-chain fatty acids. Results from experimental mice are shown on the left and from control animals on the right. Metabolites measured in the experimental group are the significantly different (_p_≤0.05) from the pre-treatment levels through day 0 (N-acety-valine, N-acetyl-aspartate), day 2 (creatine, creatinine, equol, N-acetyl-methionine, N-acetyl-aspartate), at day 2 (taurocholate,) and days 6 and 12 (6-beta-hydroxylithocholate, valerate). Error bars represent standard error.