Metabolomics Analysis Identifies Intestinal Microbiota-Derived Biomarkers of Colonization Resistance in Clindamycin-Treated Mice (original) (raw)
Figure 10
Changes in levels of fecal metabolites of piperacillin/tazobactam-treated mice compared to saline controls for selected compounds that increased or decreased in concentration during treatment followed by normalization or substantial return to baseline within 8 days.
Compounds from pathways related to metabolism of (A) 4- and 5-carbon alcohols and (B) sugars, (C) dipeptides, (D) inositol isomers and metabolites and (E) gamma-glutamyl amino acids. Results from experimental mice are shown on the left and from control animals on the right. Metabolites measured in the experimental group are the significantly different (_p_≤0.05) from the pre-treatment levels through day 0 (ribitol, xylulose, pyroglutamylglutamine, gamma-glutamylvaline, day 6 (arabitol, erythritol, chiro-inositol, gamma-glutamylisoleucine, gamma-glutamylmethionine), at day 6 (threitol) or through day 2 (all other metabolites). Error bars represent standard error.