Maresin Biosynthesis and Identification of Maresin 2, a New Anti-Inflammatory and Pro-Resolving Mediator from Human Macrophages (original) (raw)
Figure 7
Proposed biosynthetic scheme for MaR1 and MaR2.
Human macrophage 12-LOX converts DHA to the 13S,14S-epoxy-maresin intermediate, and via soluble epoxide hydrolase this intermediate is converted to MaR2. See text for details and stereochemical assignments.