The mGluR5 Antagonist Fenobam Induces Analgesic Conditioned Place Preference in Mice with Spared Nerve Injury (original) (raw)
Figure 4
MPEP induces place preference in male SNI mice only.
(A) SNI mice (n = 8) spent significantly more total time in the MPEP-paired chamber compared to vehicle-paired chamber on post-conditioning day 5. (B) Sham mice (n = 8) show no difference in the total amount of time spent in MPEP and vehicle-paired chamber on post-conditioning day 5. (C) SNI mice increase the amount of time they spend in the MPEP-paired chamber on day 5 (post-conditioning) compared to baseline (day 1 pre-conditioning) while (D) sham mice show no such difference. Paired t-test, *p<0.05, **p<0.01.