Fgfr1 Inactivation in the Mouse Telencephalon Results in Impaired Maturation of Interneurons Expressing Parvalbumin (original) (raw)
Figure 6
No differences in apoptotic cell death in postnatal interneurons at P0 or P7 of Fgfr1 mutant mice.
No differences in total Active Caspase 3 positive cells, or in GFP/Active Caspase 3 double positive cells were observed in Fgfr1f/f;Gad67-GFP+ control and Fgfr1f/f;hGFAP-Cre;Gad67-GFP+ mutant mice at P0 (A, n = 4 controls, n = 3 Fgfr1 mutants) or at P7 (B, n = 4 controls, n = 5 Fgfr1 mutants). No differences in the number of GFP positive interneurons were observed at P7 (C), indicating that the loss of GFP staining seen in adult animals is occurring after P7. Representative staining of activated caspase 3 and GFP (D). Scale bar is 5 µm.