The Periplasmic Protein TolB as a Potential Drug Target in Pseudomonas aeruginosa (original) (raw)
Figure 5
TolB depletion increases P. aeruginosa sensitivity to polymyxins in a killing assay.
Survival of PAO1 wild-type cells (filled circles) and TolB-deficient mutant cells (open diamonds), obtained as shown in Figure 3A, after 1-h treatment with 4, 1 or 0.25 mg/L of colistin (left panel), or 2, 0.5 or 0.125 mg/L of polymyxin B (right panel). Values are expressed as percent survival compared to untreated cells, and the results represent the mean (± SD) of three independent experiments. **, P<0.01 (one-way ANOVA).