Overexpression of Dyrk1A Is Implicated in Several Cognitive, Electrophysiological and Neuromorphological Alterations Found in a Mouse Model of Down Syndrome (original) (raw)
Figure 6
Normalization of the Dyrk1A gene dosage increased cell proliferation and differentiation in the DG but did not rescue the density of mature granule neurons.
(a) Representative images of Ki67, DCX, CLR and DAPI labeling in the DG. (b) Mean values ± SEM of the density of Ki67-, DCX-, CLR- and DAPI-positive cells of TS mice trisomic (+/+/+) and disomic (+/+/−) for Dyrk1A and euploid (CO +/+) mice. Ki67: ANOVA ‘trisomy’: F(1,17) = 5.60, p = 0.032; ‘Dyrk1A’: F(1,17) = 7.31, p = 0.017. DCX: ANOVA ‘trisomy’: F(1,17) = 7.37, p = 0.016; ‘Dyrk1A’: F(1,17) = 3.79,; p = 0.071. CLR: ANOVA ‘trisomy’: F(1,17) = 0.94 p = 0.34; ‘Dyrk1A’: F(1,17) = 5.56, p = 0.032. DAPI: ANOVA ‘trisomy’: F(1173) = 13.43, p = 0.003; ‘Dyrk1A’: F(1,17) = 1.77, p = 0.20. *: p<0.05 TS +/+/+ vs. CO +/+; #: p<0.05 TS +/+/− vs. TS +/+/+; Bonferroni tests after significant MANOVAs.