Formation of Fenestrae in Murine Liver Sinusoids Depends on Plasmalemma Vesicle-Associated Protein and Is Required for Lipoprotein Passage (original) (raw)
Figure 5
Hyperlipoproteinemia in _Plvap_-deficient mice.
A, Plasma of a P10 _Plvap_-deficient pup looks milky (arrows), while that from a wild-type littermate is clear. No obvious differences in hematocrit readings are observed between a _Plvap_-/- pup and its wild-type littermate (right-handed panel). B, The blood in the mesenterial or kidney vessels of a 3-week-old _Plvap_-deficient animal is milky (white arrows), while that of wild-type animals is red. Boxed area displays a magnification of mesenteric capillaries that are cut open to show milky blood (black arrow). Kidneys and livers of wild-type animals are of reddish color (black arrows), while those of _Plvap_-deficient littermates are pale.