Detection of a Novel, Integrative Aging Process Suggests Complex Physiological Integration (original) (raw)
Fig 9
Stability across datasets of correlations between age and PCA axes or biomarkers.
Biomarkers are sorted from highest to lowest |loading| in PCA1. Colored boxes indicate significant correlations (p<0.05) with darker shading indicating stronger correlation (blue = positive, red = negative). Note that many biomarkers are significantly correlated in opposite directions in different datasets. Boxes are absent for variables with insufficient sample size in the respective dataset. The weak correlation between age and PCA1 in the youngest subgroup is expected given the non-linear relationship with age (Fig. 8).